Arsenal's exit at the hands of Championship side Sheffield Wednesday was the shock of the night as Arsene Wenger's men were soundly beaten 3-0.

Arsenal gave full debuts to two of their youth players but were left counting the cost as both Alex Oxlade Chamberlain and Theo Walcott were injured during the match.

Chelsea's exit at Stoke was perhaps not as surprising as it normally would be given the Premier League champions poor form this season. Jose Mourinho has come under fire for his side's performances as well as his behavior off the pitch, which has seen him have several run ins with the FA.

Mourinho however was in a positive mood  despite going out of the competition which his side won last season, insisting his side's performance showed that his players were still playing for him, contrary to reports in the media of unrest in the dressing room.

With Championship side Hull City and Everton joining Sheffield Wednesday and Stoke in the last eight, both halves of Manchester will be fancying themselves to go all the way in the competition, providing they progress this evening.

City take on Crystal Palace, who are enjoying life under Alan Pardew this season and will be looking to cause an upset.

Manuel Pellegrini will be giving some of his squad players a run out tonight but not by choice, with the likes of Sergio Aguero, David Silva, Yaya Toure, and Samir Nasri all out with injury.

For United, they face a side who have had success last time they visited Manchester in a cup competition. Championship side Middlesbrough knocked United's City rivals out of the FA Cup last season, and will be hoping for a similar result.

Elsewhere, Liverpool will look to get their first win under new manager Jurgen Klopp against struggling Bournemouth, whilst Southampton take on Aston Villa, who are playing their first game since the sacking of manager Tim Sherwood.